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. 2018 Oct 11;2018:8919867. doi: 10.1155/2018/8919867

Figure 2.

Figure 2

Effect of inhibitors of TRPV4, SKca, and IKca on EDHF-mediated dilation and hyperpolarization induced by TFR (n=6 in each group). L-NAME (an inhibitor of nitric oxide synthase), 30 μmol/L; Indo (indomethacin, an inhibitor of cyclooxygenase), 10 μmol/L. (a) Effect of inhibitors of TRPV4 (HC-067047), SKca (Apamin), IKca (TRAM-34) on EDHF-mediated dilation induced by TFR. (b) Effect of inhibitors of TRPV4, SKca, and IKca on EDHF-mediated hyperpolarization of cerebral vascular smooth muscle cells induced by TFR. ∗P<0.05; ∗∗P<0.01 versus IR (L-NAME+Indo). Comparisons were made by unpaired Student's t-test.