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. 2018 Oct 25;27(11):1876–1892. doi: 10.1002/pro.3496

Figure 2.

Figure 2

NR DNA binding domains. (A) Cartoon representation of NR DBDs indicating important motifs. This domain contains two subdomains, each containing one zinc finger. The first subdomain residues interact with the DNA major groove to make base‐specific interactions on genomic response elements. The second subdomain participates in DBD dimerization and makes non‐specific contacts with the DNA backbone. Some NRs, like LRH‐1 and GCNF, also contain C‐terminal extensions (CTEs) that make base‐specific contacts with the minor groove. (B) Cartoon representation of folded GR DBD highlighting the important regions (PDB: http://firstglance.jmol.org/fg.htm?mol=3FYL). Zinc atoms are represented as spheres.