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NR ligand binding domains. Cartoon representation of the structurally conserved NR LBD. This domain is composed of 11 α‐helices and 4 β‐strands that fold into three layers of a helical sandwich bundle. This fold creates a hydrophobic ligand binding pocket at the bottom of the receptor. This domain also contains the AF surface, composed of H3, H4, and the AF‐H, which interacts with co‐regulator proteins (PDB: http://firstglance.jmol.org/fg.htm?mol=1PZL).
