Table 2.
Distribution of genotypes of SLC2A1 variants.
| Variant | Genotype | DM + DN N (%) | DM-DN N (%) | HC N (%) | *p Value | **ORG (95% CI) |
|---|---|---|---|---|---|---|
| rs12407920 | C C | 154 (79.4) | 124 (80.5) | 212 (88.0) | .044 | 1.55 (1.09–2.19) |
| C T | 38 (19.6) | 30 (19.5) | 26 (10.8) | |||
| T T | 2 (1.0) | 0 (0) | 3 (1.2) | |||
| rs2297976 | G G | 122 (63.9) | 96 (64.0) | 153 (63.2) | .973 | 0.99 (0.76–1.29) |
| G T | 62 (32.5) | 48 (32.0) | 82 (33.9) | |||
| T T | 7 (3.7) | 6 (4.0) | 7 (2.9) | |||
| rs710221 | G G | 66 (34.6) | 49 (33.3) | 77 (32.9) | .930 | 0.98 (0.77–1.24) |
| G A | 89 (46.6) | 74 (50.3) | 118 (50.4) | |||
| A A | 36 (18.8) | 24 (16.3) | 39 (16.7) | |||
| rs2086856 | A A | 86 (44.8) | 73 (48.7) | 111 (46.6) | .369 | 1.11 (0.87–1.41) |
| A G | 80 (41.7) | 64 (42.7) | 108 (45.4) | |||
| G G | 26 (13.5) | 13 (8.7) | 19 (8.0) | |||
| rs12130264 | C C | 176 (90.3) | 136 (89.5) | 209 (87.1) | .492 | 0.80 (0.52–1.23) |
| C T | 17 (8.7) | 16 (10.5) | 30 (12.5) | |||
| C C | 2 (1.0) | 0 (0.0) | 1 (0.4) | |||
| rs841847 | C C | 86 (44.8) | 71 (46.7) | 147 (60.2) | .015 | 1.49 (1.16–1.89) |
| C T | 87 (45.3) | 67 (44.1) | 79 (32.4) | |||
| T T | 19 (9.9) | 14 (9.2) | 18 (7.4) | |||
| rs841853 | C C | 70 (36.3) | 61 (41.2) | 126 (52.3) | .018 | 1.46 (1.15–1.86) |
| C A | 99 (51.3) | 69 (46.6) | 91 (37.8) | |||
| A A | 24 (12.4) | 18 (12.2) | 24 (10.0) | |||
| rs3729548 | C C | 71 (36.8) | 48 (32.9) | 72 (30.0) | .240 | 0.78 (0.62–0.98) |
| C T | 94 (48.7) | 69 (47.3) | 113 (47.1) | |||
| T T | 28 (14.5) | 29 (19.9) | 55 (22.9) | |||
| rs841855 | G G | 129 (68.3) | 113 (75.8) | 169 (70.4) | .509 | 1.05 (0.79–1.41) |
| G A | 55 (29.1) | 31 (20.8) | 65 (27.1) | |||
| A A | 5 (2.6) | 5 (3.4) | 6 (2.5) | |||
| rs3768029 | C C | 54 (28.6) | 32 (21.3) | 65 (26.6) | .213 | 0.86 (0.68–1.08) |
| C T | 100 (52.9) | 82 (54.7) | 115 (47.1) | |||
| T T | 35 (18.5) | 36 (24.0) | 64 (26.2) | |||
| rs12071418 | C C | 189 (97.9) | 147 (96.1) | 231 (96.7) | .583 | 0.76 (0.36–1.58) |
| C G | 4 (2.1) | 6 (3.9) | 8 (3.3) | |||
| G G | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||
| rs3820549 | C C | 102 (53.1) | 86 (56.2) | 124 (50.8) | .842 | 0.94 (0.74–1.20) |
| C G | 72 (37.5) | 56 (36.6) | 98 (40.2) | |||
| G G | 18 (9.4) | 11 (7.2) | 22 (9.0) | |||
| rs3820546 | G G | 49 (25.8) | 42 (27.6) | 70 (29.0) | .362 | 0.96 (0.77–1.20) |
| G A | 107 (56.3) | 75 (49.3) | 113 (46.9) | |||
| A A | 34 (17.9) | 35 (23.0) | 58 (24.1) | |||
| rs11537641 | G G | 131 (67.9) | 107 (70.9) | 159 (66.0) | .484 | 0.91 (0.69–1.20) |
| G A | 58 (30.1) | 39 (25.8) | 70 (29.0) | |||
| A A | 4 (2.1) | 5 (3.3) | 12 (5.0) |
Distribution of genotypes of SLC2A1 variants among cases with T2DM-nephropathy (T2DM-nephropathy; DM + DN), diseased (T2DM without nephropathy; DM-DN) and healthy (HC) control subjects. *χ2p Values and **the generalized odds ratio (ORG) with respective 95% confidence intervals (95% CI) calculated for testing the association between genotype distribution of each variant and disease progression. ORG and p values are in bold in case of statistical significance.