Table 6.
Estimated haplotype frequencies for the 14 SLC2A1 variants.
| Estimated frequencies |
χ2 | Global | |||
|---|---|---|---|---|---|
| Haplotypes of SNPs 1–14* | DM + DN | HC | Odds ratio (95%CI) | p-Value | p-Value |
| C G A G C C C C A C C G G A | 0.127 | 0.121 | 1.009 (0.638–0.597) | .969 | .132 |
| C T A A C T A C G C C C A G | 0.074 | 0.067 | 1.063 (0.594–0.902) | .838 | |
| C G G A C C C T G T C C A G | 0.285 | 0.290 | 0.908 (0.637–0.292) | .591 | |
| C G G A T C C T G T C C A G | 0.010 | 0.038 | 0.248 (0.075–0.817) | .014 | |
| C T A A C T A C G C C C G G | 0.097 | 0.060 | 1.633 (0.927–0.875) | .087 | |
| C G G A C T A C G C C C G G | 0.031 | 0.015 | 2.067 (0.726–0.888) | .165 | |
| T G G G C T A C G C C C G G | 0.032 | 0.041 | 0.732 (0.330–0.627) | .443 | |
| C G G A C C C T G T C C G G | 0.039 | 0.048 | 0.773 (0.371–0.610) | .491 | |
| C G G A C T A C G C C G G G | 0.044 | 0.029 | 1.481 (0.667–0.288) | .332 | |
Estimated haplotype frequencies for the 14 SLC2A1 variants (SNPs 1–14: rs12407920 C/T, rs2297976 G/T, rs710221 G/A, rs2086856 A/G, rs12130264 C/T, rs841847 C/T, rs841853 C/A, rs3729548 C/T, rs841855 G/A, rs3768029 C/T, rs12071418 C/G, rs3820549 C/G, rs3820546 G/A, rs11537641 G/A) in cases (T2DM-nephropathy; DM + DN) and in healthy controls (HC). The p values for comparison between cases and HC of the frequencies of each haplotype and the global p values for testing the overall difference in haplotype frequencies are shown.
*
Only haplotypes with a frequency of >0.03 in either cases (DM + DN) or controls (HC) are shown. OR and p values are in bold in case of statistical significance.