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. 2018 Sep 27;9:574. doi: 10.3389/fendo.2018.00574

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Copyright © 2018 Liu, He, Ning, Luo, Li, Zhang, Chen and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative transcriptomic analysis of HCD or HFD-induced obese Nile tilapia. (A) Validation of RNA-Seq data by qRT-PCR. The left profile shows mRNA expression patterns of 24 representative genes detected by RNA-Seq, and the right one is the corresponding verification results by qRT-PCR. EF1α was used as an internal control. (B) The number of DEGs among all samples. (C) Distribution by categories of DEGs when compared HCD and HFD treatment to control. FDR ≤ 0.05 and |log₂ (fold change)| ≥1 were set as the thresholds to identify DEGs. (D) DEGs involved in metabolic pathways of DIO Nile tilapia. Relative expression levels were normalized based on the Z-score and are shown on a color gradient from low (green) to high (red). GCK, glucokinase; PK, pyruvate kinase; LDH, lactate dehydrogenase; G6Pase, glucose 6-phosphatase; F1,6BPase, fructose 1,6-bisphosphatase; PEPCKc, phosphoenolpyruvate carboxykinase cytosol isozyme; GK, glycerol kinase; ALDH9A1, aldehyde dehydrogenase 9 family, member A1; BCAT2, branched-chain-amino-acid aminotransferase; SHMT, serine hydroxymethyltransferase; EAAT1, excitatory amino acid transporter 1; SLC7A11, solute carrier family 7 member 11; SLC6A4, solute carrier family 6 member 4; SNAT2, sodium-coupled neutral amino acid transporter 2; SNAT3, sodium-coupled neutral amino acid transporter 3; SLC43A1, solute carrier family 43 member 1; ACOX3, acyl-coenzyme A oxidase 3; CACT, carnitine-acylcarnitine translocase; FABP1, fatty acid-binding protein 1; ACSBG, acyl-CoA synthetase, bubblegum Family; ACSL, long chain fatty acid-CoA ligase; ApoE, apolipoprotein E; DGAT, diglyceride acyltransferase; HSL, hormone-sensitive lipase; ATGL, adipose triglyceride lipase; MPC1, mitochondrial pyruvate carrier 1; SLC25A11, solute carrier family 25 member 11; PDHc, pyruvate dehydrogenase complex; PEPCKm, phosphoenolpyruvate carboxykinase mitochondrial isozyme; CPT1, carnitine palmitoyl transterase 1; ACADL, acyl-CoA dehydrogenase long chain; HADHA, hydroxyacyl-Coenzyme A dehydrogenase; ACAT1, acetyl-CoA acetyltransferase 1; HMGCL, hydroxymethylglutaryl-CoA lyase; CS, citrate synthase; IDH, isocitrate dehydrogenase; OGDH, ketoglutarate dehydrogenase.