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. 2018 Sep 27;9:574. doi: 10.3389/fendo.2018.00574

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Copyright © 2018 Liu, He, Ning, Luo, Li, Zhang, Chen and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DIO Nile tilapia presented hyperleptinemia and LR. (A) Plasma Leptin levels (n = 5). (B,C) LepA mRNA levels in liver and SCAT (n = 6). (D) SOCS3, PTP1B and NPY mRNA levels in hypothalamus (n = 6). (E,F) Western blot analysis of LepA in liver and SCAT, and column diagram shows as LepA relative to GAPDH (n = 4). (G,H) IHC for LepA (brown, indicated by red arrows) in liver and SCAT. Scale bars, 50 μm. (I) Western blot analysis of p-STAT3 in hypothalamus, and column diagram is shown as p-STAT3 relative to STAT3 (n = 4). (J) Hypothalamic p-STAT3 with NtrelepA administration. (K) Food intake rate at 2 h after NtrelepA or saline treatment (n = 6). (L) 24-h weight gain after NtrelepA or saline treatment. NtrelepA group (9 ND fish, 8 HCD fish, and 9 HFD fish) and saline group (10 ND fish, 8 HCD fish, and 10 HFD fish). ^*p < 0.05 and ^**p < 0.01. Data shown as means ± SEM.