Table 1. Connectivity map analysis of human breast cancer MDA-MB-231 cells after Ran silencing using shRNA.
| Compound | Replicates | Set score | p-value | stdev | zscore |
|---|---|---|---|---|---|
| Pimozide | 4 | -0.8084 | 0.00001 | 0.16833 | -4.8028 |
| SC-58125 | 4 | -0.7283 | 0.00001 | 0.16583 | -4.392 |
| Pimethixene | 3 | -0.8298 | 0.00004 | 0.1952 | -4.2507 |
| Fluorocurarine | 4 | -0.6746 | 0.00004 | 0.16231 | -4.1563 |
| Chlorphenesin | 4 | -0.8019 | 0.00001 | 0.19792 | -4.0514 |
| Ouabain | 4 | -0.7897 | 0.0001 | 0.19517 | -4.0463 |
| Emetine | 4 | -0.8836 | 0.00002 | 0.22767 | -3.8812 |
| Vinpocetine | 4 | -0.8086 | 0.00002 | 0.2174 | -3.7193 |
| HNMPA-(AM)3 | 1 | -0.9356 | 0.00002 | 0.28851 | -3.2427 |
| Oxamic acid | 1 | -0.9337 | 0.00002 | 0.28851 | -3.2363 |
| Tomelukast | 1 | 0.93609 | 8.00E-05 | 0.28851 | 3.24454 |
| Equilin | 5 | 0.73566 | 2.00E-05 | 0.17639 | 4.17066 |
| Promethazine | 4 | -0.7215 | 0.00004 | 0.18346 | -3.9326 |
| Etacrynic acid | 3 | -0.7908 | 0.00002 | 0.20202 | -3.9146 |
| Cortisone | 3 | -0.8615 | 0.00002 | 0.2284 | -3.7716 |
| Oxymetazoline | 4 | -0.8091 | 0.00001 | 0.2239 | -3.6139 |
| Sulfamethoxypyridazine | 5 | -0.8193 | 0.00002 | 0.2271 | -3.6074 |
| Dipyridamole | 6 | -0.734 | 0.00006 | 0.20596 | -3.5638 |
| Cotinine | 6 | -0.7913 | 0.00006 | 0.22281 | -3.5512 |
| Ronidazole | 3 | -0.8361 | 0.00008 | 0.25165 | -3.3224 |
| Lobeline | 4 | 0.43885 | 8.00E-05 | 0.12488 | 3.51418 |
| Docosahexaenoic acid ethyl ester | 2 | 0.82579 | 0.00001 | 0.22997 | 3.59087 |
| Alpha-yohimbine | 3 | 0.75844 | 0.00012 | 0.20143 | 3.76532 |
| Esculetin | 3 | 0.81007 | 6.00E-05 | 0.21378 | 3.78931 |