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. 2018 Oct 9;9(79):34876–34888. doi: 10.18632/oncotarget.26172

Figure 2. Kaplan–Meier curves of E-SCC patients in relation to CD44v8-10 expression.

Figure 2

(A) Among all subjects (n = 73), high CD44v8-10 expression in pre-dCRT biopsy specimens was significantly correlated with poor prognosis after dCRT (p = 0.001). (B) In cStage I (cT1b) patients, there was no significant difference in overall survival between patients with high and low CD44v8-10 expression (p = 0.439). However, in cStage II + III (C) and cStage IVA + IVB (with cM1-lym) patients (D), high CD44v8-10 expression was correlated with poor prognosis (p = 0.024 and p = 0.023, respectively). Abbreviations: E-SCC, esophageal squamous cell carcinoma; dCRT, definitive chemoradiotherapy; cStage, clinical stage in Union for International Cancer Control 8th edition; cT1b, tumor invades the submucosa; cM1-lym, distant lymph node metastasis; OS overall survival; CI, confidence interval; N/A, not applicable.