Table 1. Characteristics of subjects with esophageal squamous cell carcinoma (E-SCC).
| Age | Mean ± SD, (y) | 69 | ± 8.2 |
| Gender | Male | 61 | (83.6%) |
| Female | 12 | (16.4%) | |
| Height | Mean ± SD, (cm) | 161.1 | ± 8.0 |
| Weight | Mean ± SD, (kg) | 53.9 | ± 8.8 |
| eGFR | Mean ± SD, (ml/min/1.73m2) | 78 | ± 20.5 |
| PS | 0 | 18 | (24.7%) |
| 1 | 39 | (53.4%) | |
| 2 | 16 | (21.9%) | |
| 3 | 0 | (0.0%) | |
| Tumor size | Median with range, (cm) | 5.0 (1.0–10.5) | |
| Tumor location (primary site) | Ce | 9 | (12.3%) |
| Ut | 11 | (15.1%) | |
| Mt | 35 | (47.9%) | |
| Lt | 18 | (24.7%) | |
| EGJ | 0 | (0.0%) | |
| Histological type | Well differentiated SCC | 10 | (13.7%) |
| Moderately differentiated SCC | 54 | (74.0%) | |
| Poorly differentiated SCC | 9 | (12.3%) | |
| Basaloid SCC | 0 | (0.0%) | |
| Depth of invasion | cTis | 0 | (0.0%) |
| cT1a | 0 | (0.0%) | |
| cT1b | 15 | (20.5%) | |
| cT2 | 9 | (12.3%) | |
| cT3 | 22 | (30.1%) | |
| cT4a | 12 | (16.4%) | |
| cT4b | 15 | (20.5%) | |
| Lymph node metastasis | cN0 | 24 | (32.9%) |
| cN1 | 12 | (16.4%) | |
| cN2 | 32 | (43.8%) | |
| cN3 | 5 | (6.8%) | |
| Distant metastasis | cM0 | 63 | (86.3%) |
| cM1-lym | 10 | (13.7%) | |
| cM1-hematogenous or (pleural/peritoneal) dissemination | 0 | (0.0%) | |
| cStage, UICC 8th | 0 | 0 | (0.0%) |
| I | 14 | (19.2%) | |
| II | 8 | (11.0%) | |
| III | 16 | (21.9%) | |
| IVA | 25 | (34.2%) | |
| IVB (cM1-lym) | 10 | (13.7%) | |
| IVB with hematogenous metastasis or (pleural/peritoneal) dissemination | 0 | (0.0%) | |
| Number of pre-CRT tumor biopsy sample | Median with range, (n) | 2 (1–6) | |
| CD44v8-10 expression | Median with range, (H-score) | 180 (5–300) | |
Abbreviations: SD, standard deviation; eGFR, estimated glomerular filtration rate; PS, performance status according to Eastern Cooperative Oncology Group criteria; CE, cervical esophagus; Ut, upper thoracic esophagus; Mt, middle thoracic esophagus; Lt, lower thoracic esophagus; EGJ, esophago-gastric junction; cT1a, tumor invades the muscularis mucosa; cT1b, tumor invades the submucosa; cT2, tumor invades the muscularis propria; cT3, tumor invades the adventitia; cT4a, tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum; cT4b, tumor invades other adjacent structures, such as the aorta, vertebral body, or trachea; cStage, clinical stage group of squamous cell carcinoma in Union for International Cancer Control 8th edition; cN0, no regional lymph node metastasis; cN1, metastasis in 1–2 regional lymph nodes; cN2, metastasis in 3–6 regional lymph nodes; cN3, metastasis in 7 or more regional lymph nodes; cM0, no distant metastasis; cM1-lym, distant lymph node metastasis; CRT, chemoradiotherapy; H-score, histo-score.
All values indicate n (%) unless otherwise indicated.