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. 2018 Oct 15;14(10):e1007348. doi: 10.1371/journal.ppat.1007348

Fig 2. Mutation of dltA and lytR renders GAS more susceptible to hGIIA, whereas mutation of gacI increases hGIIA resistance in multiple GAS serotypes.

Fig 2

Deletion of (A) dltA or (B) lytR increases GAS susceptibility to hGIIA-mediated killing in a concentration-dependent manner. Deletion of gacI renders GAS more resistant to hGIIA-mediated killing as shown for (C) 5448 and (D) other tested GAS serotypes. Data represent mean +/- SD of three independent experiments. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001.