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. 2018 Oct 15;14(10):e1007678. doi: 10.1371/journal.pgen.1007678

Fig 1. RET mutations harbored by patient ID 0110M.

Fig 1

Integrative Genomics Viewer visualization and Sanger sequencing confirmation of NGS data showing the synonymous p.Cys630 = substitution and the somatic p.Cys634Arg mutation (arrows). The variations were identified in (A) the primary MTC, (B and C) two metastatic lesions removed in April 2010, and (D) a third metastatic lesion removed after discontinuation of vandetanib. The germ-line substitution was also identified in DNA from the pre-thyroidectomy blood sample (E).