Table 4. Patient- and Vessel-Based Diagnostic Performance of 1.5T and 3T CMR Perfusion Imaging for Detecting Significant Coronary Stenoses Compared with ICA.
All Patients | Patients without MI | |||
---|---|---|---|---|
1.5T CMR | 3T CMR | 1.5T CMR | 3T CMR | |
Per patient | ||||
TP (n) | 62 | 55 | 34 | 34 |
FP (n) | 22 | 22 | 15 | 16 |
TN (n) | 39 | 55 | 39 | 55 |
FN (n) | 12 | 14 | 8 | 14 |
Sensitivity (%) | 84 (73–91) | 80 (68–88) | 81 (66–91) | 71 (56–83) |
Specificity (%) | 64 (51–76) | 71 (60–81) | 72 (58–83) | 77 (66–87) |
PPV (%) | 74 (67–80) | 71 (63–78) | 69 (59–78) | 68 (57–77) |
NPV (%) | 76 (65–85) | 80 (71–86) | 83 (68–84) | 80 (71–86) |
Accuracy (%) | 75 (67–82) | 75 (68–82) | 76 (72–90) | 75 (66–82) |
Kappa statistic | 0.49 (0.34–0.64) | 0.51 (0.37–0.65) | 0.52 (0.35–0.69) | 0.48 (0.32–0.64) |
AUC | 0.75 ± 0.04 (0.67–0.82) | 0.76 ± 0.04 (0.69–0.83) | 0.77 ± 0.04 (0.67–0.85) | 0.74 ± 0.04 (0.65–0.82) |
P | 0.74 | 0.68 | ||
Per vessel territory | ||||
TP (n) | 90 | 82 | 29 | 47 |
FP (n) | 46 | 46 | 22 | 31 |
TN (n) | 227 | 283 | 200 | 258 |
FN (n) | 42 | 27 | 37 | 21 |
Sensitivity (%) | 68 (64–73) | 75 (66–83) | 44 (38–50) | 69 (57–80) |
Specificity (%) | 83 (80–87) | 86 (82–90) | 90 (85–92) | 89 (85–93) |
PPV (%) | 66 (61–71) | 64 (57–70) | 57 (45–68) | 60 (51–69) |
NPV (%) | 84 (81–88) | 91 (88–94) | 84 (81–87) | 93 (89–95) |
Accuracy (%) | 78 (74–82) | 83 (80–87) | 80 (74–84) | 85 (81–89) |
Kappa statistic | 0.51 (0.42–0.60) | 0.58 (0.49–0.67) | 0.36 (0.21–0.50) | 0.55 (0.44–0.67) |
AUC | 0.76 ± 0.02 (0.71–0.80) | 0.81 ± 0.02 (0.77–0.84) | 0.67 ± 0.03 (0.61–0.72) | 0.79 ± 0.03 (0.75–0.83) |
P | 0.22 | 0.006 |
Values for sensitivity, specificity, PPV, NPV, accuracy, kappa statistic, and AUC presented with 95% CIs. AUC expressed as mean ± standard error. AUC = area under receiver operating characteristic curve, CIs = confidence intervals, FN = false negative, FP = false positive, NPV = negative predictive value, PPV = positive predictive value, TN = true negative, TP = true positive