Table 5. Models predictive of prognosis of acute liver injury among subjects with acute DILI from the US DILIN—death at 6 months vs survived.
| Variable | Acute Death | Survived | Sensitivity (95% CI) |
Specificity (95% CI) |
Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) | Accuracy (95% CI) |
|---|---|---|---|---|---|---|---|
| Serum albumin | |||||||
| < = 2.8 g/dL | 10 | 15 | 56% (47%, 64%) |
86% (80%, 92%) |
40% (31%, 49%) |
92% (87%, 97%) |
82% (75%, 89%) |
| >2.8 g/dL | 8 | 94 | |||||
| MELD score at baseline (+/- 7 days)* | |||||||
| ≥17 | 16 | 42 | 94% (90%, 98%) |
58% (50%, 67%) |
28% (20%, 36%) |
98% (96%,100) |
64% (55%, 72%) |
| <17 | 1 | 59 | |||||
| RANTES [pg/mL] below median |
15 | 49 | 83% (77%, 90%) |
55% (46%, 64%) |
23% (16%, 31%) |
95% (92%, 99%) |
59% (51%, 68%) |
| RANTES above median | 3 | 60 | |||||
| RANTES and serum albumin | |||||||
| RANTES below median and albumin ≤2.8 g/dL | 7 | 10 | 39% (30%, 47%) |
91% (86%, 96%) |
41% (33%, 50%) |
90% (85%, 95%) |
83% (77%, 90%) |
| RANTES above median or albumin >2.8 g/dL | 11 | 99 |
Median value for RANTES was 11,349 pg/mL
*Some subjects had missing MELD score.