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. 2018 Oct 18;13:6585–6602. doi: 10.2147/IJN.S178819

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© 2018 Eltobshi et al. This work is published and licensed by Dove Medical Press Limited

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Immunostained rats paw skin against caspase-3.

Notes: (A) Thin skin and (B) thick skin. (I) Normal group showing negative staining, (II) positive control exhibiting strong staining, (III) rats pretreated with 100 mg/kg Dcn showing moderate staining, (IV) and (V) rats pretreated with 1:10 Dcn:Glc SNEDDSs or 1:8 Dcn:TPGS SNEDDS, respectively, exhibiting mild staining. IHC counterstained with Mayer’s hematoxylin (100×); insert (S, 200×).

Abbreviations: Dcn, diacerein; Glc, gelucire 44/14; TPGS, d-α-tocopheryl polyethylene glycol 1,000 succinate; SNEDDS, self-nanoemulsifying drug-delivery system; IHC, immunohistochemically.