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Edema (A) and edema inhibition (B) in groups pretreated orally with 100 mg/kg Dcn or an equivalent dose of the two optimized SNEDDSs in comparison with the positive carrageenan group.
Abbreviations: Dcn, diacerein; Glc, gelucire 44/14; TPGS, d-α-tocopheryl polyethylene glycol 1,000 succinate; SNEDDS, self-nanoemulsifying drug-delivery system.
