Table 3.

Kinetic analysis of drug-release data during burst-release phase

Formula code	Correlation coefficient (r2)			Release order	Korsmeyer		Main release mechanism
	Zero-order	First-order	Higuchi model		n	r2
Glc
PM 1:1	0.9515	0.9222	0.8711	Zero	1.93	0.9674	Supercase II
PM 1:2	0.9541	0.9914	0.9907	First	1.47	0.9176	Supercase II
PM 1:4	0.9929	0.9865	0.9661	Zero	1.39	0.9914	Supercase II
PM 1:6	0.9991	0.9908	0.9838	Zero	1.69	0.9175	Supercase II
PM 1:8	0.9892	0.9866	0.9651	Zero	1.42	0.981	Supercase II
PM 1:10	0.9826	0.9944	0.9823	First	1.4	0.9635	Supercase II
SNEDDS 1:1	0.8949	0.9447	0.924	First	2.03	0.918	Supercase II
SNEDDS 1:2	0.9207	0.9759	0.9596	First	1.79	0.9102	Supercase II
SNEDDS 1:4	0.8809	0.9702	0.9403	First	1.17	0.9223	Supercase II
SNEDDS 1:6	0.9029	0.9892	0.9549	First	1.33	0.9212	Supercase II
SNEDDS 1:8	0.8877	0.9929	0.9471	First	1.44	0.899	Supercase II
SNEDDS 1:10	0.8362	0.988	0.9125	First	1.4	0.8717	Supercase II
TPGS							Supercase II
PM 1:1	0.8805	0.9142	0.914	First	2.52	0.9182	Supercase II
PM 1:2	0.9053	0.9445	0.9322	First	1.97	0.9492	Supercase II
PM 1:4	0.9121	0.949	0.9408	First	1.86	0.9456	Supercase II
PM 1:6	0.9271	0.9683	0.942	First	1.84	0.9622	Supercase II
PM 1:8	0.9444	0.9803	0.9622	First	1.8	0.935	Supercase II
PM 1:10	0.9471	0.9806	0.9498	First	1.67	0.9599	Supercase II
SNEDDS 1:1	0.9764	0.9799	0.9599	First	2.38	0.9534	Supercase II
SNEDDS 1:2	0.973	0.98	0.9607	First	1.8	0.9606	Supercase II
SNEDDS 1:4	0.9687	0.9926	0.9839	First	1.49	0.9593	Supercase II
SNEDDS 1:6	0.9665	0.9928	0.9876	First	1.6	0.9425	Supercase II
SNEDDS 1:8	0.9106	0.9703	0.9671	First	1.08	0.9289	Supercase II
SNEDDS 1:10	0.9299	0.9781	0.9759	First	1.18	0.938	Supercase II

Abbreviations: n, diffusion exponent; Glc, gelucire 44/14; TPGS, d-α-tocopheryl polyethylene glycol 1,000 succinate; PM, physical mixture; SNEDDS, self-nanoemulsifying drug-delivery system.