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Models for the influence of W409 in GIIβ enhancement of GII activity.33 In both models, the catalytic GIIα subunit interacts with the GIIβ subunit (labeled in white) through the small G2B domain as well as through other yet to be defined contacts. In model A, the MRH domain enhances the catalytic activity of the GIIα subunit by W409 interacting with the B arm of the glycan. In model B, the W409 aromatic group interacts with a portion of the GIIβ subunit and enhances binding.
