TABLE 3.
HfpEF on PI (n = 57) |
HfpEF on NPI (n = 115) |
p Value | |
---|---|---|---|
Female | 24 (43) | 56 (49) | 0.415 |
BMI, kg/m2 | 28.0± 5.6 | 27.0± 5.6 | 0.272 |
Age, yrs | 60.0± 9.0 | 60.0± 9.4 | 0.994 |
Race | |||
Hispanic | 19 (34) | 35 (30) | 0.701 |
African American | 26 (46) | 49 (43) | |
Others | 12 (21) | 31 (27) | |
CV risk factors | |||
Diabetes | 26 (45) | 40 (35) | 0.169 |
Hypertension | 36 (64) | 64 (56) | 0.348 |
Hyperlipidemia | 31 (54) | 40 (35) | 0.014 |
Smoking | 20 (35) | 59 (51) | 0.044 |
CAD | 28 (49) | 33 (29) | 0.008 |
Myocarditis | 8 (14) | 13 (11) | 0.626 |
Cocaine | 26 (46) | 32 (28) | 0.020 |
SBP, mm Hg | 144.0± 25.8 | 141.0± 26.6 | 0.483 |
DBP, mm Hg | 78± 18.8 | 79± 18.2 | 0.737 |
Heart rate, beats/min | 80.0± 23.2 | 82.0± 22.7 | 0.590 |
PASP, mm Hg | 47.0± 9.9 | 40.0± 8.1 | <0.001 |
LVEF, % | 57.0± 5.3 | 56.0± 5.0 | 0.231 |
SA | 16 (28) | 36 (31) | 0.663 |
HCV | 11 (20) | 25 (22) | 0.711 |
HIV parameters | |||
CD4 count at 1st HF admission, cells/mm3 | 276± 215 | 291± 193 | 0.645 |
Nadir CD4 count, cells/mm3 | 218± 185 | 272± 191 | 0.080 |
VL <200 copies/ml | 34 (60) | 72 (63) | 0.707 |
Duration of ART, yrs | 8 (4–14) | 9 (4–14) | 0.842 |
Duration of PI, yrs | 6 (4–11) | – | – |
Duration of HIV* | 8 (4–14) | 9 (4–14) | 0.842 |
Duration of untreated HIV† | 75 (46–104) | 74 (46–106) | 0.632 |
Socioeconomic parameters | |||
High school or GED completion | 38 (66) | 72 (63) | 0.601 |
Unemployment | 7(13) | 14 (12) | 0.983 |
ART medications | |||
NRTIs | 57 (100) | 115 (100) | >0.05 |
INSTIs | 3(5) | 44 (38) | <0.001 |
NNRTIs | 4(7) | 71 (62) | <0.001 |
HF medications | |||
Beta-blocker | 48 (85) | 102 (89) | 0.468 |
ACE inhibitor or ARB | 47 (83) | 99 (86) | 0.651 |
Spironolactone | 0(0) | 0(0) | |
Furosemide | 39 (69) | 92 (80) | 0.093 |
Values are n (%), mean± SD, or median (interquartile range). Bold p values are statistically significant.
Duration of HIV is in years.
Duration of untreated HIV is the duration before starting ART after the diagnosis in days.
HFpEF = heart failure with preserved ejection fraction; other abbreviations as in Table 1.