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Assessment of TFP toxicity in vitro and in vivo. (A) CCK-8 for determining the cytotoxicity of TFP in SHG44 and SHG44/DOX cells (n=9). (B) Animal body weights of 4-week-old nude mice were measured following injection with various doses of TFP for 7, 14, 21, and 28 days (n=15 mice, n=3 experiments). *P<0.05, **P<0.01 and ***P<0.001, compared with the control group at the same time point. DOX, doxorubicin; TFP, trifluoperazine.
