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. 2018 Sep 21;42(6):3115–3124. doi: 10.3892/ijmm.2018.3891

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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BMPR2 is a direct target of miR-1307-3p. The expression of BMPR2 during chondrogenic differentiation was examined by (A) RT-qPCR and (B) western blot analyses. (C) Predicted binding site of miR-1307-3p in the 3′UTR of BMPR2 is shown. (D) hADSCs were transfected with the indicated plasmids, and the luciferase activities were determined using a dual luciferase assay. hADSCs were infected with the indicated recombinant lentivirus, and (E) mRNA and (F) protein levels of BMPR2 were analyzed by RT-qPCR and western blot analyses, respectively. ^*P<0.05, ^**P<0.01 and ^***P<0.001. miR, microRNA; hADSCs, human adipose-derived stem cells; BMPR2, bone morphogenetic protein receptor type 2; 3′UTR, 3′ untranslated region; wt, wild-type; mut, mutant; NC, negative control; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; NS, not significant; d, day.