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. 2018 Oct 1;42(6):3371–3385. doi: 10.3892/ijmm.2018.3907

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Age-associated decline of Nrf2 signaling in the auditory cortex. (A) Representative immunofluorescence images stained with anti-Nrf2 antibody. (B) Quantitative presentation of the fluorescence intensity of Nrf2 in the nucleus. mRNA levels of (C) NQO1, (D) HO-1 and (E) MnSOD in the auditory cortex. For all experiments, ^*P<0.05, vs. age-matched NS group; ^#P<0.05 and ^##P<0.01, vs. 4-month-old NS group; ^{^}P<0.05 and ^{^^}P<0.01, vs. 4-month-old D-gal group. The data are presented as the mean ± standard deviation. Nrf2, NF-E2-related factor 2; NQO1, NAD(P)H quinone oxidoreductase 1; HO-1, heme oxygenase-1; MnSOD, manganese superoxide dismutase; NS, normal saline; D-gal, D-galactose.