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. 2018 Oct 1;42(6):3220–3230. doi: 10.3892/ijmm.2018.3903

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of fisetin on nephritis in SLE models. (A) Histological PAS staining of glomeruli in PRI-induced mice. Representative images are displayed. Scale bar=50 µm. (B) The activity index for each group was determined from the PAS-stained tissue sections. (C) The chronicity index of PAS-stained renal tissue sections was measured. (D) Serum BUN and (E) creatinine were examined. Values are expressed as the mean ± standard error of the mean (n=10 in each group). ^***P<0.001 vs. the Con group; ⁺P<0.05, ⁺⁺P<0.01 and ⁺⁺⁺P<0.001 vs. the PRI group. Con, control; PRI, pristine; PAS, periodic acid-Schiff; BUN, blood urea nitrogen; F50/100, treatment with 50/100 mg/kg fisetin.