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. Author manuscript; available in PMC: 2019 Aug 4.
Published in final edited form as: J Cell Physiol. 2018 Aug 4;234(1):369–381. doi: 10.1002/jcp.26930

Figure 9.

Figure 9

Proposed mechanism underlying miR-638-induced inhibition of airway smooth muscle cell proliferation and migration in asthmas. Pathological stimuli, such as PDGF-BB and TGF-β, downregulate the expression of miR-638, which in turn leads to an increased expression of cyclin D1 and orphan nuclear receptor NOR1 and a subsequent AMS hyperplasia in asthma.