Table 1:
Patient characteristics
| Characteristic | N (%) | Without GR2+ pneumonitis (N = 23) | With GR2+ pneumonitis (N = 5) |
|---|---|---|---|
| Age at time of radiation treatment (years) | Median: 70.5 Range: 53–81 |
Median: 75 Range: 53–80 |
Median: 67 Range: 55–81 |
| Sex | |||
| Male | 11 (39) | 8 | 3 |
| Female | 17 (61) | 15 | 2 |
| Clinical stage | |||
| Limited stage SCLC | 5 (18) | 4 | 1 |
| I NSCLC | 5 (18) | 4 | 1 |
| II NSCLC | 1 (4) | 0 | 1 |
| IIIA NSCLC | 4 (14) | 3 | 1 |
| IIIB NSCLC | 4 (14) | 4 | 0 |
| Locally recurrent | 5 (18) | 4 | 1 |
| Metastatic to lung | 4 (14) | 4 | 0 |
| Histology | |||
| NSCLC | 20 (71) | 16 | 4 |
| SCLC | 5 (18) | 4 | 1 |
| Other (other primary) | 3 (11) | 3 | 0 |
| Prior thoracic radiation | |||
| Yes | 6 (21) | 6 | 0 |
| No | 22 (79) | 17 | 5 |
| Concurrent chemotherapy | |||
| Yes | 10 (36) | 6 | 4 |
| No | 18 (64) | 17 | 1 |
| EQD2 radiation dose (Gy) | Median: 60 Range: 48–66.6 |
Median: 66 Range: 60–66.6 |
Median: 60 Range: 48–66.6 |
| Radiation treatment technique | |||
| 3D CRT | 1 (4) | 1 | 0 |
| IMRT/VMAT | 10 (36) | 7 | 3 |
| SBRT | 7 (24) | 7 | 0 |
| PBT | 10 (36) | 8 | 2 |
| Smoking status | |||
| Lifetime nonsmoker | 5 (18) | 4 | 1 |
| Former | 19 (68) | 15 | 4 |
| Current | 4 (14) | 4 | 0 |
| Pre-existing emphysema | |||
| Yes | 14 (50) | 12 | 2 |
| No | 14 (50) | 11 | 3 |
SCLC small cell lung cancer, NSCLC non-small cell lung cancer, EQD2 equivalent dose in 2 Gy per fraction, 3D CRT three-dimensional conformal radiation therapy, IMRT/VMAT intensity-modulated radiotherapy/volumetric modulated arc therapy, SBRT stereotactic body radiation therapy, PBT proton beam therapy