Table 3.
Genome-wide significant regions of local African ancestry associated with type 2 diabetes in the Black Women’s Health Study
| Locus | ||
|---|---|---|
| 3q26.33 | 12q23.1 | |
| Zcase-only, P-value | 4.01, 6.0×10−5 | 4.42, 9.8×10−6 |
| Zcase-control, P-value | 2.79, 5.3×10−3 | 2.70, 7.0×10−3 |
| Per African allele OR (95% CI)1, cases/controls | ||
| All subjects, 2632/2596 | 1.23 (1.09–1.39) | 1.13 (1.00–1.29) |
| Among non-obese2, 814/1622 | 1.19 (0.98–1.44) | 1.34 (1.10–1.63) |
| Among obese2, 1818/974 | 1.29 (1.10–1.53) | 0.99 (0.83–1.18) |
1
Association of locus-specific African ancestry with type 2 diabetes adjusting for individual African ancestry, age, geographic region of residence, neighborhood socioeconomic status, years of education, and BMI (continuous)
2
Non-obese, BMI<30 kg/m2; obese, BMI≥30 kg/m2