Skip to main content
. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: J Hum Genet. 2018 Aug 22;63(11):1109–1117. doi: 10.1038/s10038-018-0503-2

Table 4.

Type 2 diabetes GWAS index SNPs with P<0.05 in the Black Women’s Health Study

Locus Chromosome SNP1 GWAS OR Alleles2 EAF3 BWHS results
BWHS AFR EUR OR4 (95% CI) P-value
GCKR 2p23 rs780094 1.06 C/T 0.82 0.87 0.59 1.11 (1.00–1.23) 0.049
ANKRD55 5q11 rs459193 1.08 G/A 0.58 0.53 0.71 1.09 (1.01–1.18) 0.037
KCNK16 6p21 rs1535500 1.13 T/G 0.83 0.90 0.49 0.88 (0.79–0.98) 0.021
DGKB 7p21 rs6960043 1.06 C/T 0.24 0.17 0.47 0.89 (0.81–0.98) 0.016
JAZF1 7p15 rs864745 1.10 T/C 0.74 0.79 0.48 1.14 (1.04–1.25) 0.0039
TP53INP1 8q22 rs896854 1.06 T/C 0.69 0.74 0.46 1.18 (1.08–1.29) 1.8×10−4
SLC30A8 8q24 rs13266634 1.12 C/T 0.90 0.93 0.72 1.27 (1.11–1.45) 4.7×10−4
TCF7L2 10q25 rs7903146 1.40 T/C 0.30 0.26 0.32 1.20 (1.10–1.31) 2.4×10−5
KCNQ1 11p15 rs231362 1.08 G/A 0.77 0.80 0.50 1.14 (1.04–1.26) 0.0052
DUSP9 Xq26 rs5945326 1.27 A/G 0.79 0.82 0.75 1.11 (1.01–1.22) 0.038
1

All index SNPs were directly genotyped in the Affymetrix Axiom 45K custom array

2

Effect allele/reference allele

3

Effect allele frequency; BWHS = Black Women’s Health Study, AFR = African population from 1KGP, EUR = European population from 1KGP

4

Odds ratios adjusted for % African ancestry, age, and geographic region of residence