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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: J Hum Genet. 2018 Aug 22;63(11):1109–1117. doi: 10.1038/s10038-018-0503-2

Table 5.

New significant signals in type 2 diabetes loci in the Black Women’s Health Study

Locus Index SNP Best SNP1 r2 with index
EUR/AFR
SNP, alleles2 EAF3 OR4 (95% CI),
P-value		 SNP, alleles2 EAF3 OR4 (95% CI),
P-value
BWHS EUR BWHS EUR
PROX1
1q32		 rs2075423, G/T 0.63 0.63 1.03 (0.95–1.12), 0.49 rs120914475, A/G 0.97 0.98 1.55 (1.24–1.95), 1.1×10−4 <0.01/<0.01
ANKRD55
5q11		 rs459193, G/A 0.58 0.71 1.09 (1.01–1.18), 0.037 rs73127858, T/C 0.11 0.001 1.29 (1.14–1.47), 7.1×10−5 0.0/0.0
GLIS3
9p24		 rs7041847, A/G 0.87 0.53 1.10 (0.98–1.24), 0.11 rs1145607815, C/A 0.02 0.0 1.80 (1.35–2.39), 6.6×10−5 0.0/0.0
TCF7L2
10q25		 rs7903146, T/C 0.30 0.32 1.20 (1.10–1.31), 2.4×10−5 rs114770437, G/A 0.93 1.0 1.37 (1.18–1.61), 6.4×10−5 0.0/0.03
HMGA2
12q14		 rs1531343, C/G 0.37 0.13 0.99 (0.91–1.07), 0.74 rs2583943, A/G 0.81 0.16 1.25 (1.12–1.39), 5.7×10−5 0.67/0.03
rs1163330535, A/C 0.05 0.001 1.44 (1.19–1.74), 1.8×10−4 <0.01/<0.01
1

Most significant SNP with locus-wide significant fine-mapping results

2

Effect allele/reference allele

3

Effect allele frequency in the current study (BWHS), and European (EUR) ancestry populations from 1000 Genomes Project

4

Odds ratios adjusted for % African ancestry, age, and geographic region of residence

5

Imputed SNPs: rs12091447 info = 0.93; rs114560781 info = 0.95; rs116333053 info = 0.94