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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1738–1747. doi: 10.1161/ATVBAHA.118.311367

Figure 3. Reduced expression of thermogenic genes in PVAT and iBAT upon PPARγ deletion in brown adipocytes.

Figure 3.

(A). mRNA profile of genes related to thermogenesis in PVAT, interscapular BAT (iBAT), subcutaneous WAT (sWAT) and gonadal WAT (gWAT). The mRNA level was normalized by 18S, with the level in wild-type mice set at 1. Data are shown as mean ± SD. n=5 mice/group. Student t-test between two groups for each gene, *p<0.05 vs wild-type. (B). Protein levels of uncoupling protein 1 (UCP1) and PR/SET Domain 16 (PRDM16) in iBAT of wild-type and BA-PPARγ-KO mice. (C). Temperature change (ΔTemperature) in iBAT in response to acute cold stimuli to the hind paws and tail of wild-type and BA-PPARγ-KO mice. Data are shown as mean ± SD. n=6 mice/group. Statistical analysis was performed by multiple comparisons with repeated measures after two-way ANOVA,**p<0.01 vs wild-type.