TABLE 3c.
Admission Multiple Electrode Platelet Aggregometry, Coagulation Results, and Factor Activity Any-TBI (iTBI + pTBI) vs. Non-TBI
| TBI (n=54) | Non-TBI (n=179) | p-value | |
|---|---|---|---|
| ADP AUC | 60 (48–70) | 60 (46–71) | 0.69 |
| Collagen AUC | 51 (38–63) | 49 (40–61) | 0.92 |
| TRAP AUC | 99 (82–118) | 97 (82–111) | 0.50 |
| AA AUC | 60 (40–69) | 61 (49–71) | 0.35 |
| Ristocetin AUC | 57 (38–77) | 69 (46–88) | 0.03 |
| Overall low platelet response (%) | 44% | 34% | 0.15 |
| Admit INR>1.3 | 10% | 4% | 0.14 |
| Admit INR | 1.1 (1.1–1.2) | 1.1 (1–1.1) | <0.01 |
| Admit PTT (sec) | 28 (26–32) | 28 (25–30) | 0.06 |
| Admit platelets (x 109/L) | 269 (217–310) | 262 (224–306) | 0.66 |
| Factor II (% activity) | 69 (59–80) | 72 (61–84) | 0.28 |
| Factor V (% activity) | 50 (36–68) | 61 (43–80) | 0.10 |
| Factor VII (% activity) | 70 (60–90) | 83 (62–100) | 0.05 |
| Factor VIII (% activity) | 215 (132–346) | 156 (97–221) | 0.01 |
| Factor IX (% activity) | 122 (105–151) | 137 (107–166) | 0.21 |
| Factor X (% activity) | 76 (60–83) | 79 (66–90) | 0.17 |
Data reported as median with inter-quartile ranges. Platelet aggregation was induced by agonist stimulation with adenosine diphosphate (ADP, via P2 receptors), collagen (via GpIa/IIa and GpVI receptors), thrombin receptor activating peptide-6 (TRAP, via PAR receptors), arachidonic acid (AA, via the cyclooxygenase pathway), or ristocetin (via vWF complex). Platelet adhesion to the electrodes was detected as increasing electrical impedance, measured by duplicate sets of sensor wires in each test cell. Platelet aggregation responses to multiple electrode platelet aggregometry are reported as area under the aggregation curve in units (U) over a 6-minute measurement period. p-values bolded for <0.05