Table 2.

Comparison of characteristics between CAA and non-CAA cases (hospital-based pathology cohort) and between HCHWA-D mutation carriers and non-carriers (Dutch cohort).

Sporadic CAA cohort (n=63)	CAA+ cases	CAA− cases	p value
Age by MRI, mean ± SD	73.1 ± 8.2	74.9 ± 9.3	0.46
Female sex, n(%)	22(47.9)	7(41.2)	0.78
Hypertension, n(%)	30(65.2)	11(64.7)	0.99
High burden basal ganglia PVS, n(%)	5(10.9)	10(58.8)	0.0002
WMH volume in cc, median[IQR]	26.3[11.6 – 44.8]	26.5[5.6 – 58.9]	0.84
Presence of any lobar hemorrhage, n(%)	38(82.6)	7(41.2)	0.003
CSO-PVS relative volume, median % [IQR]	3.7[2.5 – 5.3]	1.8[1.2 – 2.4]	<0.0001
Dutch cohort (n=54)	Mutation carriers	Non-carriers	p value
Age by MRI, mean ± SD	45.8 ± 13.9	47.5 ± 11.8	0.55
Female sex, n(%)	16(61.5)	17(60.7)	0.99
Hypertension, n(%)	6(23)	6(21.4)	0.99
High burden basal ganglia PVS, n(%)	2(7.7)	2(7.1)	0.99
WMH volume in cc, median[IQR]	38.8[1.5 – 117.9]	0.6[0.2 – 2.3]	0.0007
Presence of any lobar hemorrhage, n(%)	17(65.4)	2(7.1)	<0.0001
CSO-PVS relative volume, median% [IQR]	3.8[0.6 – 6.2]	0.7[0.4 – 1.6]	0.007