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. Author manuscript; available in PMC: 2018 Nov 16.
Published in final edited form as: Nat Chem Biol. 2018 May 16;14(6):538–541. doi: 10.1038/s41589-018-0054-z

FIGURE 1. PglC reveals a distinct architecture and topology for monotopic membrane proteins.

FIGURE 1

a, Predicted position of PglC with respect to the membrane, including the reentrant membrane helix (RMH) formed by the helix-break-helix motif of helices A and B (N to C termini colored blue to red). b, Depiction of the PglC active site showing the conserved Asp–Glu dyad with Mg2+ and phosphate ligands and sequence logo. c, The AHABh (alpha-helix-associated beta-hairpin)-motif that defines the superfamily fold is formed by a β-hairpin comprising β-strands 1 and 2 packing against helix D.