Table 1.
Histopathology of adrenals from patients stratified by biochemical outcome after adrenalectomy
| VARIABLE | Total cohort N (%) |
BIOCHEMICAL OUTCOME |
P-value |
|
|---|---|---|---|---|
| A + P | C | |||
| Total | 95 (100 %) | 43 (45 %) | 52 (55 %) | |
| Solitary functional adenoma | 60 (63 %) | 19 (44 %) | 41 (79 %) | < 0.001 |
| Normal appearing adjacent cortex | 29 (48 %) | 9 (47 %) | 20 (49 %) | 0.919 |
| Hyperplasia | 9 (15 %) | 5 (26 %) | 4 (10 %) | 0.200 |
| APCC | 30 (50 %) | 10 (53 %) | 20 (49 %) | 0.781 |
| No functional adenoma | 35 (37 %) | 24 (56 %) | 11 (21 %) | < 0.001 |
| CYP11B2 negative adenoma | 9 (26 %) | 7 (29 %) | 2 (18 %) | 0.403 |
| Hyperplasia | 23 (66 %) | 16 (67 %) | 7 (64 %) | 0.576 |
| APCC | 27 (77 %) | 18 (75 %) | 9 (81 %) | 0.508 |
| Hyperplasia | 32 (34 %) | 21 (49 %) | 11 (21 %) | 0.004 |
| APCC | 57 (60 %) | 28 (65 %) | 29 (56 %) | 0.355 |
| APCC number (sample section) | 3.2 ± 2.9 | 3.2 ± 3.1 | 3.3 ± 2.8 | 0.641 |
APA, aldosterone-producing adenoma; A, P and C refer to absent, partial and complete biochemical success after surgery; APCC, aldosterone-producing cell cluster; CYP11B2, aldosterone synthase. Values indicate absolute numbers with proportions in parenthesis (%) or average numbers ± SD. P values were calculated using a χ² or Fisher’s exact tests or Mann-Whitney tests as appropriate.