Table 2.
Population-level model parameters and standard deviations describing the expected dose-function response in well-perfused voxels at baseline (95% confidence intervals)
| RT modality/time point | N | E[αj] = α | sd[αj] | E[μj] = μ | sd[μj] |
|---|---|---|---|---|---|
| Conventional RT/Mid-Tx | 54 | 0.22 (0.16–0.27) | 0.21 (0.17–0.26) | 9.8 (4.1–15.5) | 17.9 (13.9–23.1) |
| Conventional RTOMonth Post-Tx | 37 | 0.72 (0.62–0.81) | 0.28 (0.22–0.35) | 18.2 (14.4–22.1) | 10.9 (8.2–14.4) |
| Conventional RT/lYear Post-Tx | 19 | 1.00 (0.80–1.21) | 0.44 (0.28–0.69) | 21.8 (8.9–34.7) | 28.1 (19.8–40.0) |
| SBRT/Mid-Tx | 20 | 0.24 (0.12–0.37) | 0.27 (0.18–0.40) | 45.0 (28.9–61.2) | 35.3 (24.5–50.9) |
| SBRT/3Month Post-Tx | 14 | 0.56 (0.46–0.66) | 0.19 (0.13–0.27) | 13.9 (4.4–23.3) | 17.0 (10.8–26.7) |
| SBRT/1 Year Post-Tx | 7 | 0.86 (0.56–1.15) | 0.39 (0.23–0.67) | 21.8 (18.3–25.3) | - |
| RT modality/time point | γ | σ | λ | ||
| Conventional RT/Mid-Tx | 5.4 (4–0-6.8) | 0.22 (0.19–0.26) | −0.11 (−0.13 to −0.08) | ||
| Conventional RTOMonth Post-Tx | 9.6 (8.5–10.7) | 0.32 (0.24–0.41) | −0.13 (−0.17 to −0.10) | ||
| Conventional RT/1Year Post-Tx | 10.3 (8.7–12.0) | 0.16 (0.10–0.25) | −0.03 (−0.10 to 0.03) | ||
| SBRT/Mid-Tx | 14.0 (11.5–16.5) | 0.10 (0.09–0.11) | −0.06 (−0.07 to −0.04) | ||
| SBRTOMonth Post-Tx | 12.1 (9.9–14.4) | 0.11 (0.10–0.13) | −0.01 (−0.04 to 0.01) | ||
| SBRT/1Year Post-Tx | 20.4 (16.4–24.3) | 0.12 (0.09–0.15) | 0.03 (−0.03 to 0.08) | ||
Abbreviations: 1Year Post-Tx = 1 year post-treatment; 3Month Post-Tx = 3 months post-treatment; Mid-Tx = midcourse treatment; SBRT Z stereotactic body radiation therapy.
Models with “-“ listed in the sd[μj] column were unable to converge using patient-specific midpoints; thus, the same population-level midpoint was given to all patient in that cohort.