Table 3.
Population-level model parameters and standard deviations describing the expected dose-function response stratified by functional categorization at baseline (95% confidence intervals)
| RT modality/time point | E[αj] = α | sd[αj] | E[μj] = μ | sd[μj] | γ |
|---|---|---|---|---|---|
| Conventional RT/Mid-Tx | 0.71 (−0.25 to 1.66) | − | 46.6 (−102.6 to 195.8) | - | 53.8 (−5.4 to 113.1) |
| Conventional RT/3Month Post-Tx | 1.26 (1.19–1.33) | 0.16 (0.13–0.21) | 25.1 (20.6–29.6) | 13.2 (10.3–16.9) | 13.0 (11.9–14.1) |
| Conventional RT/1Year Post-Tx | 1.23 (1.10–1.37) | 0.23 (0.16–0.32) | 17.9 (14.9–20.9) | - | 15.4 (12.6–18.1) |
| SBRT/Mid-Tx | 0.51 (0.43–0.59) | 0.13 (0.09–0.18) | 34.2 (19.1–49.3) | 58.4 (41.5–75.2) | |
| SBRT/3Month Post-Tx | 0.86 (0.77–0.94) | 0.16 (0.11–0.23) | 14.6 (4.0–25.1) | 19.8 (13.4–29.2) | 13.3 (11.6–15.1) |
| SBRT/1Year Post-Tx | 1.19 (1.02–1.36) | 0.22 (0.13–0.38) | 26.0 (14.1–37.9) | 15.8 (9.1–27.2) | 15.1 (13.3–16.9) |
| RT modality/time point | ω1 | ω2 | ω3 | σ | λ |
| Conventional RT/Mid-Tx | −0.90 (0.32 to −2.12) | −0.72 (0.26 to −1.69) | −0.45 (0.16 to −1.07) | 0.51 (0.46–0.57) | −0.15 (−0.17 to −0.14) |
| Conventional RT/3Month Post-Tx | −1.17 (−1.13 to –1.22) | −0.89 (−0.85 to −0.93) | −0.53 (−0.49 to −0.56) | 0.29 (0.25–0.32) | −0.10 (−0.12 to −0.08) |
| Conventional RT/1Year Post-Tx | −1.15 (−1.06 to −1.24) | −0.85 (−0.77 to −0.93) | −0.53 (−0.46 to −0.59) | 0.44 (0.37–0.53) | −0.12 (−0.14 to −0.09) |
| SBRT/Mid-Tx | −0.57 (−0.50 to −0.63) | −0.43 (−0.38 to −0.49) | −0.29 (−0.25 to −0.33) | 0.21 (0.20–0.22) | −0.09 (−0.10 to −0.08) |
| SBRT/3Month Post-Tx | −0.83 (−0.81 to −0.86) | −0.58 (−0.55 to −0.60) | −0.32 (−0.30 to −0.35) | 0.17 (0.16–0.18) | −0.07 (−0.08 to −0.05) |
| SBRT/1Year Post-Tx | −1.04 (−0.98 to −1.09) | −0.69 (−0.64 to −0.73) | −0.38 (−0.33 to −0.43) | 0.27 (0.25–0.30) | −0.13 (−0.14 to −0.11) |
Abbreviations: 1Year Post-Tx = 1 year post-treatment; 3Month Post-Tx = 3 months post-treatment; GTV = gross tumor volume; Mid-Tx = midcourse treatment; SBRT = stereotactic body radiation therapy.
Models with “-" listed in the sd[μj] column were unable to converge using patient-specific midpoints; thus, the same population-level midpoint was given to all patient in that cohort. The number of patients contributing to each model is the same as shown in Table 2.