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. 2018 Oct 25;8:15752. doi: 10.1038/s41598-018-33982-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PHA-767491 does not sensitise non-AML HSCs to ABT-737. CD34⁺ non-malignant HSCs were isolated from four patients with non-AML disorders. These cells were cultured on an HS5-BMSC monolayer for 24 h and then treated with ABT-737 (30 and 300 nM) with or without a 4 h pre-treatment with the CDC7/CDK9 inhibitor, PHA-767491 (1–4 µM). Induction of cell death was quantified with To-Pro-3 staining and flow cytometry. The graphs show the percentage of live blasts. The effect of PHA-767491 alone is shown by the points on the Y axis (zero ABT-737 concentration) and the effect of ABT-737 alone is shown by the PHA 0 µM line (open circles).