Fig. 3.

E6 contacts the HECT domain of E6AP. a Shown are the identified interlinks between E6AP and E6. Lysine residues and regions of known functions within E6AP and E6 are color-coded as in Fig. 1. b List with identified interlinks between E6AP and E6. Numbering is according to human E6AP isoform 1³³. Links which can be mapped to existing PDB structures (4XR8; 1C4Z) are highlighted. c Structural model of the binding interface between the HECT domain of E6AP and E6. The localization densities of the HECT domain of E6AP (residues 495–846) and E6 (residues 1–151) are shown in sand yellow and light green, respectively, with a single representative ribbon structure embedded. For clarity, UbcH7, a cognate E2 of E6AP, was also added and is shown in yellow (PDB: 1C4Z). Detected interlinks between E6 and E6AP that map to PDB structures 4XR8 and 1C4Z, respectively, are highlighted in orange. The catalytic cysteine on position C820 in the HECT domain of E6AP is shown as a red ball. The model is shown from the top (left) and from a side view (right)