Fig. 1.

C1GALT1 is overexpressed in HNSCC tumors and high C1GALT1 expression predicts poor prognosis. a C1GALT1 messenger RNA expression in HNSCC. Data are retrieved from Peng Head-Neck and TCGA Head-Neck in the Oncomine database (https://www.oncomine.org). b Left panel, western blot analysis of C1GALT1 expression in paired HNSCC tumor tissues (T) with adjacent non-tumor mucosa (N) from 8 patients. GAPDH was an internal control. Right panel, C1GALT1 expression was quantified and analyzed by paired Student’s t-test. *P < 0.05. c Scores of C1GALT1 expression from 0 to 3 in HNSCC tissues analyzed using immunohistochemistry. Scale bars, 50 µm. d Kaplan–Meier survival analysis. Patients with follow-up period over 36 months are included (n = 146). Left and right panels indicate disease-free and overall survivals, respectively