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. 2018 Oct 25;8:15776. doi: 10.1038/s41598-018-34083-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The non-invasive ICP waveform estimate (nICP, interrupted red line) is shown together with the invasive ICP waveform (continuous red line) for four different 6-second time windows after the beginning of the measurement (patient ID 3). The time delay between the nICP and ICP signals, as seen in Fig. 2a, has been removed for visual comparison.