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. 2018 Oct 25;8:15810. doi: 10.1038/s41598-018-34082-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of the computational model. The reconstructed arterial geometry represents the bifurcation of the internal carotid artery (ICA) into the anterior cerebral artery (ACA, left branch) and the MCA (right branch). Compartmental model solves transient plasma concentrations of free phase proteins for a given therapeutic regimen which are then used as inputs for the 3D clot dissolution model.