Table 1.

Kinetic constants in the compartmental model.

Symbol	Value	Units	Source
C AP,0	1	µM	44
C Fbg,0	8	µM	10, 18, 45
C PLG,0	2.0	µM	10, 46
C PLS,0	0	µM	10
C tPA,0	0.07 × 10−3	µM	47
k 2,f	0.3	1/s	19
k AP	10	1/(µM∙s)	10
k cat,f	6	1/(µM∙s)	Derived from18
K M,f	28	µM	19
t 1/2,AP	2.64	days	48
t 1/2,FBG	4.14	days	45
t 1/2,PLG	2.2	days	46
t 1/2,PLS	0.1	s	49
t 1/2,tPA	4	mins	5, 18
V plasma	3.9	L	Max. volume for 80 kg patient45
M w,tPA	59.04	mg/µmol	—