Table 7.
Comparison of relative expression of 44 candidate genes between healthy controls (smokers and non-smokers) and COPD smoker patients (stage I and stage II) in age groups separately.
| Age group | Gene Symbol | Healthy Non-Smoker (N = 45) | Healthy Smoker (N = 50) | COPD smoker (N = 10) | COPD stage I smoker (N = 5) | COPD stage II smoker (N = 5) | Fold Regulation, adjusted p-value (HS vs. HNS) | Fold Regulation, adjusted p-value (COPD vs. HS) | Fold Regulation, adjusted p-value (stage I vs. HS) | Fold Regulation, adjusted p-value (stage II vs. HS) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| <50 years old | 1. | PPP4R4 | 6.56 ± 0.77 | 6.01 ± 0.86 | 5.23 ± 0.60 | 5.64 ± 0.43 | 4.84 ± 0.48 | −1.091,0.009 | −1.149, 0.005 | −1.065, 0.99 | −1.242, 0.009 |
| 2. | THSD4 | 7.65 ± 0.47 | 7.36 ± 0.56 | 7.24 ± 0.47 | 7.47 ± 0.33 | 7.02 ± 0.51 | −1.039, 0.049 | −1.017, 0.579 | 1.015, 0.99 | −1.049, 0.91 | |
| 3. | NRG1 | 3.81 ± 0.26 | 4.05 ± 0.45 | 3.89 ± 0.50 | 4.06 ± 0.62 | 3.72 ± 0.29 | 1.064, 0.008 | −1.041, 0.131 | 1.002, 0.99 | −1.090, 0.336 | |
| 4. | SCGB1A1 | 14.50 ± 0.15 | 14.36 ± 0.19 | 14.01 ± 0.41 | 14.15 ± 0.33 | 13.88 ± 0.47 | −1.010, 0.005 | −1.025, 0.009 | −1.015, 0.149 | −1.035, 0.001 | |
| 5. | AHRR | 3.87 ± 0.15 | 4.53 ± 0.63 | 5.27 ± 0.73 | 5.66 ± 0.71 | 4.91 ± 0.59 | 1.168, 0.001 | 1.163, 0.004 | 1.250, 0.001 | 1.085, 0.618 | |
| 6. | CYP1A1 | 4.61 ± 0.24 | 5.95 ± 1.79 | 7.91 ± 2.16 | 8.22 ± 1.81 | 7.61 ± 2.67 | 1.290, 0.001 | 1.329, 0.008 | 1.381, 0.007 | 1.278, 0.046 | |
| 7. | CYP1B1 | 3.64 ± 0.53 | 7.54 ± 2.04 | 9.75 ± 1.17 | 10.23 ± 0.54 | 9.30 ± 1.53 | 2.072, 0.001 | 1.293, 0.003 | 1.357, 0.006 | 1.234, 0.17 | |
| 8. | PRDM11 | 5.72 ± 0.36 | 5.36 ± 0.34 | 5.20 ± 0.31 | 5.30 ± 0.18 | 5.11 ± 0.40 | −1.067, 0.001 | −1.031, 0.193 | −1.011, 0.99 | −1.048, 0.82 | |
| 9. | CBR3 | 7.26 ± 0.43 | 8.10 ± 0.68 | 8.58 ± 0.59 | 8.74 ± 0.41 | 8.44 ± 0.75 | 1.116, 0.001 | 1.059, 0.039 | 1.079, 0.155 | 1.042, 0.99 | |
| 10. | AKR1C1 | 6.92 ± 0.67 | 8.54 ± 1.14 | 8.71 ± 1.18 | 8.58 ± 1.42 | 8.85 ± 1.04 | 1.235, 0.001 | 1.020, 0.491 | 1.004, 0.99 | 1.036, 0.99 | |
| 11. | AKR1C3 | 10.31 ± 0.46 | 11.82 ± 0.73 | 12.15 ± 0.67 | 12.42 ± 0.42 | 11.88 ± 0.82 | 1.146, 0.001 | 1.028, 0.275 | 1.051, 0.266 | 1.006, 0.99 | |
| 12. | HTR2B | 3.94 ± 0.21 | 4.22 ± 0.32 | 4.29 ± 0.36 | 4.31 ± 0.51 | 4.26 ± 0.18 | 1.072, 0.001 | 1.017, 0.421 | 1.021, 0.99 | 1.010, 0.99 | |
| 13. | GRM1 | 3.74 ± 0.11 | 4.01 ± 0.30 | 4.37 ± 0.73 | 4.38 ± 0.40 | 4.36 ± 1.01 | 1.072, 0.001 | 1.090, 0.112 | 1.091, 0.068 | 1.087, 0.028 | |
| 14. | CYP4Z1 | 6.88 ± 0.58 | 6.27 ± 0.59 | 5.90 ± 0.35 | 5.89 ± 0.45 | 5.91 ± 0.27 | −1.097, 0.001 | −1.063, 0.058 | −1.065, 0.834 | −1.062, 0.903 | |
| 15. | UCHL1 | 5.33 ± 0.59 | 8.71 ± 1.50 | 10.11 ± 1.79 | 10.35 ± 1.36 | 9.88 ± 2.31 | 1.636, 0.001 | 1.161, 0.008 | 1.188, 0.049 | 1.134, 0.181 | |
| 16. | CABYR | 4.86 ± 0.29 | 6.85 ± 1.20 | 7.84 ± 1.64 | 8.52 ± 1.12 | 7.22 ± 1.99 | 1.409, 0.001 | 1.145, 0.037 | 1.244, 0.003 | 1.054, 0.99 | |
| 17. | GPRC5A | 7.58 ± 0.66 | 7.50 ± 0.45 | 8.16 ± 0.61 | 7.98 ± 0.68 | 8.35 ± 0.55 | −1.011, 0.99 | 1.088, 0.003 | 1.065, 0.392 | 1.114, 0.010 | |
| 18. | CCDC37 | 9.47 ± 0.55 | 9.34 ± 0.55 | 9.54 ± 0.66 | 9.40 ± 0.80 | 9.68 ± 0.55 | −1.013, 0.99 | 1.021, 0.433 | 1.006, 0.99 | 1.036, 0.99 | |
| 19. | GLI3 | 7.62 ± 0.39 | 6.72 ± 0.60 | 6.51 ± 0.48 | 6.61 ± 0.49 | 6.41 ± 0.49 | −1.133, 0.001 | −1.032, 0.221 | −1.017, 0.99 | −1.050, 0.99 | |
| 20. | ABCC3 | 6.96 ± 0.43 | 7.91 ± 0.62 | 7.98 ± 0.69 | 8.14 ± 0.66 | 7.82 ± 0.76 | 1.136, 0.001 | 1.009, 0.716 | 1.029, 0.99 | −1.011, 0.99 | |
| 21. | SAMD5 | 3.74 ± 0.15 | 3.97 ± 0.28 | 4.13 ± 0.62 | 4.13 ± 0.24 | 4.13 ± 0.89 | 1.060, 0.001 | 1.040, 0.455 | 1.041, 0.99 | 1.041, 0.614 | |
| 22. | RASSF10 | 7.71 ± 0.50 | 7.08 ± 0.57 | 6.41 ± 0.60 | 6.68 ± 0.36 | 6.15 ± 0.72 | −1.089, 0.001 | −1.105, 0.002 | −1.060, 0.62 | −1.152, 0.002 | |
| 23. | USP27X | 7.46 ± 0.28 | 7.16 ± 0.40 | 6.52 ± 0.50 | 6.74 ± 0.34 | 6.31 ± 0.58 | −1.041, 0.002 | −1.098, 0.001 | −1.063, 0.075 | −1.136, 0.001 | |
| 24. | NR0B1 | 3.95 ± 0.25 | 4.36 ± 0.78 | 5.15 ± 0.84 | 5.35 ± 0.90 | 4.97 ± 0.81 | 1.103, 0.003 | 1.181, 0.005 | 1.226, 0.005 | 1.139, 0.23 | |
| 25. | PLAG1 | 5.87 ± 0.55 | 5.26 ± 0.57 | 4.74 ± 0.57 | 4.93 ± 0.64 | 4.55 ± 0.49 | −1.116, 0.001 | −1.110, 0.009 | −1.067, 0.99 | −0.866, 0.045 | |
| 26. | SCGB3A1 | 14.25 ± 0.40 | 13.93 ± 0.59 | 13.48 ± 0.78 | 13.89 ± 0.51 | 13.09 ± 0.85 | −1.023, 0.025 | −1.033, 0.092 | −1.002, 0.99 | −1.064, 0.006 | |
| 27. | LHX6 | 5.33 ± 0.35 | 5.80 ± 0.44 | 6.24 ± 0.57 | 6.28 ± 0.61 | 6.20 ± 0.59 | 1.087, 0.001 | 1.076, 0.016 | 1.084, 0.084 | 1.069, 0.25 | |
| 28. | LINC00942 | 3.57 ± 0.17 | 3.85 ± 0.69 | 4.45 ± 1.28 | 4.67 ± 1.53 | 4.24 ± 1.09 | 1.079, 0.073 | 1.156, 0.18 | 1.212, 0.008 | 1.101, 0.828 | |
| 29. | REEP1 | 9.40 ± 0.60 | 9.79 ± 0.55 | 9.81 ± 0.74 | 9.91 ± 0.91 | 9.71 ± 0.63 | 1.041, 0.013 | 1.002, 0.716 | 1.013, 0.99 | −1.009, 0.99 | |
| 30. | C6orf164 | 5.53 ± 0.51 | 6.06 ± 0.56 | 6.08 ± 0.52 | 6.17 ± 0.53 | 5.99 ± 0.56 | 1.097, 0.001 | 1.003, 0.66 | 1.017, 0.99 | −1.012, 0.99 | |
| 31. | LINC00589 | 5.15 ± 0.27 | 5.38 ± 0.32 | 5.32 ± 0.29 | 5.33 ± 0.16 | 5.30 ± 0.41 | 1.045, 0.001 | −1.011, 0.848 | −1.010, 0.99 | −1.015, 0.99 | |
| 32. | JAKMIP3 | 4.50 ± 0.22 | 5.25 ± 0.61 | 6.18 ± 0.81 | 6.20 ± 0.92 | 6.16 ± 0.80 | 1.166, 0.001 | 1.177, 0.002 | 1.180, 0.001 | 1.174, 0.001 | |
| 33. | LINC00930 | 6.02 ± 0.36 | 6.90 ± 0.59 | 6.77 ± 0.71 | 6.87 ± 0.79 | 6.66 ± 0.69 | 1.146, 0.001 | −1.019, 0.716 | −1.004, 0.99 | −1.035, 0.99 | |
| 34. | DNHD1 | 6.68 ± 0.50 | 7.15 ± 0.54 | 7.37 ± 0.83 | 7.47 ± 0.98 | 7.27 ± 0.75 | 1.070, 0.001 | 1.031, 0.358 | 1.044, 0.99 | 1.017, 0.99 | |
| 35. | TMCC3 | 3.80 ± 0.28 | 4.11 ± 0.48 | 4.48 ± 0.53 | 4.56 ± 0.62 | 4.40 ± 0.48 | 1.082, 0.001 | 1.090, 0.019 | 1.109, 0.12 | 1.071, 0.85 | |
| 36. | ADH7 | 8.08 ± 0.94 | 10.78 ± 0.72 | 10.87 ± 0.60 | 11.09 ± 0.59 | 10.66 ± 0.58 | 1.335, 0.001 | 1.008, 0.804 | 1.029, 0.99 | −1.012, 0.99 | |
| 37. | PRKAR2B | 7.35 ± 0.61 | 6.46 ± 0.74 | 5.74 ± 0.51 | 5.83 ± 0.46 | 5.64 ± 0.59 | −1.137, 0.001 | −1.125, 0.004 | −1.107, 0.239 | −1.145, 0.054 | |
| 38. | GAD1 | 4.87 ± 0.56 | 6.25 ± 0.99 | 7.44 ± 0.87 | 7.26 ± 1.01 | 7.62 ± 0.78 | 1.283, 0.001 | 1.190, 0.002 | 1.162, 0.068 | 1.219, 0.005 | |
| 39. | LOC338667 | 5.41 ± 0.34 | 5.20 ± 0.24 | 5.03 ± 0.22 | 5.04 ± 0.20 | 5.03 ± 0.26 | −1.040, 0.002 | −1.034, 0.071 | −1.031, 0.99 | −1.034, 0.99 | |
| 40. | CYB5A | 4.73 ± 0.20 | 4.73 ± 0.18 | 4.61 ± 0.23 | 4.70 ± 0.19 | 4.53 ± 0.26 | −1.000, 0.99 | −1.026, 0.235 | −1.006, 0.99 | −1.043, 0.99 | |
| 41. | PIEZO2 | 7.34 ± 0.84 | 6.49 ± 0.87 | 5.71 ± 0.64 | 5.71 ± 0.79 | 5.71 ± 0.54 | −1.132, 0.001 | −1.137, 0.008 | −1.136, 0.291 | −1.135, 0.255 | |
| 42. | SLITRK6 | 8.05 ± 0.59 | 6.89 ± 0.84 | 6.01 ± 0.99 | 6.10 ± 1.31 | 5.93 ± 0.67 | −1.169, 0.001 | −1.146, 0.015 | −1.129, 0.249 | −1.161, 0.043 | |
| 43. | KCNA1 | 6.95 ± 1.04 | 5.79 ± 0.96 | 5.19 ± 0.72 | 5.27 ± 0.96 | 5.11 ± 0.47 | −1.200, 0.001 | −1.116, 0.031 | −1.098, 0.99 | −1.133, 0.658 | |
| 44. | LOC100507560 | 5.90 ± 0.71 | 5.45 ± 0.62 | 5.03 ± 0.65 | 5.01 ± 0.75 | 5.05 ± 0.63 | −1.083, 0.006 | −1.083, 0.041 | −1.087, 0.99 | −1.079, 0.99 | |
| Age group | Gene Symbol | Healthy Non-Smoker (N = 8) | Healthy Smoker (N = 9) | COPD smoker (N = 11) | COPD stage I smoker (N = 4) | COPD stage II smoker (N = 7) | Fold Regulation, adjusted p-value (HS vs. HNS) | Fold Regulation, adjusted p-value (COPD vs. HS) | Fold Regulation, adjusted p-value (stage I vs. HS) | Fold Regulation, adjusted p-value (stage II vs. HS) | |
| ≥50 years old | 1. | PPP4R4 | 6.64 ± 0.64 | 6.05 ± 1.16 | 5.87 ± 0.63 | 6.20 ± 0.23 | 5.70 ± 0.75 | −1.098, 0.99 | −1.031, 0.191 | 1.024, 0.99 | −1.062, 0.99 |
| 2. | THSD4 | 7.29 ± 0.62 | 7.15 ± 0.33 | 6.99 ± 0.53 | 7.48 ± 0.33 | 6.72 ± 0.42 | −1.019, 0.99 | −1.023, 0.366 | 1.046, 0.99 | −1.065, 0.663 | |
| 3. | NRG1 | 3.71 ± 0.18 | 4.02 ± 0.63 | 3.72 ± 0.22 | 3.80 ± 0.15 | 3.68 ± 0.25 | 1.084, 0.606 | −1.081, 0.315 | −1.059, 0.99 | −1.095, 0.447 | |
| 4. | SCGB1A1 | 14.38 ± 0.13 | 14.38 ± 0.30 | 14.27 ± 0.13 | 14.23 ± 0.10 | 14.28 ± 0.16 | 1.000, 0.99 | −1.008, 0.132 | −1.010, 0.99 | −1.007, 0.99 | |
| 5. | AHRR | 3.79 ± 0.23 | 5.13 ± 0.74 | 5.19 ± 0.82 | 5.15 ± 0.96 | 5.21 ± 0.81 | 1.353, 0.012 | 1.012, 0.92 | 1.004, 0.99 | 1.016, 0.99 | |
| 6. | CYP1A1 | 4.64 ± 0.23 | 7.88 ± 1.63 | 7.55 ± 1.46 | 7.83 ± 1.26 | 7.40 ± 1.64 | 1.698, 0.001 | −1.044, 0.763 | −1.007, 0.99 | −1.065, 0.99 | |
| 7. | CYP1B1 | 3.68 ± 0.43 | 9.76 ± 1.12 | 9.28 ± 1.15 | 9.55 ± 0.47 | 9.12 ± 1.43 | 2.650, 0.001 | −1.052, 0.546 | −1.022, 0.99 | −1.069, 0.99 | |
| 8. | PRDM11 | 5.42 ± 0.18 | 5.32 ± 0.12 | 5.35 ± 0.26 | 5.41 ± 0.27 | 5.32 ± 0.27 | −1.019, 0.99 | 1.006, 0.841 | 1.018, 0.99 | −1.000, 0.99 | |
| 9. | CBR3 | 7.06 ± 0.44 | 8.60 ± 0.54 | 8.15 ± 0.63 | 8.17 ± 0.47 | 8.14 ± 0.74 | 1.218, 0.001 | −1.055, 0.159 | −1.052, 0.99 | −1.056, 0.99 | |
| ≥50 years old | 10. | AKR1C1 | 6.20 ± 0.40 | 8.75 ± 0.90 | 7.97 ± 1.15 | 8.28 ± 1.14 | 7.80 ± 1.21 | 1.412, 0.001 | −1.098, 0.159 | −1.057, 0.99 | −1.121, 0.596 |
| 11. | AKR1C3 | 10.24 ± 0.28 | 12.18 ± 0.59 | 11.79 ± 0.63 | 11.92 ± 0.42 | 11.72 ± 0.75 | 1.190, 0.001 | −1.033, 0.269 | −1.022, 0.99 | −1.040, 0.911 | |
| 12. | HTR2B | 3.85 ± 0.21 | 4.17 ± 0.22 | 4.22 ± 0.28 | 4.05 ± 0.18 | 4.32 ± 0.28 | 1.083, 0.142 | 1.012, 0.99 | −1.028, 0.99 | 1.036, 0.99 | |
| 13. | GRM1 | 3.75 ± 0.15 | 4.37 ± 0.54 | 3.98 ± 0.17 | 3.99 ± 0.17 | 3.97 ± 0.19 | 1.164, 0.008 | −1.098, 0.056 | −1.095, 0.328 | −1.099, 0.141 | |
| 14. | CYP4Z1 | 6.58 ± 0.45 | 6.02 ± 0.45 | 5.95 ± 0.42 | 5.92 ± 0.53 | 5.96 ± 0.38 | −1.094, 0.20 | −1.012, 0.688 | −1.017, 0.99 | −1.009, 0.99 | |
| 15. | UCHL1 | 5.18 ± 0.35 | 9.51 ± 1.42 | 8.56 ± 1.54 | 8.03 ± 1.04 | 8.89 ± 1.74 | 1.836, 0.001 | −1.111, 0.269 | −1.185, 0.467 | −1.070, 0.99 | |
| 16. | CABYR | 4.89 ± 0.32 | 7.69 ± 1.35 | 7.13 ± 0.99 | 7.36 ± 0.83 | 7.00 ± 1.11 | 1.575, 0.001 | −1.079, 0.228 | −1.045, 0.99 | −1.099, 0.99 | |
| 17. | GPRC5A | 7.60 ± 0.45 | 7.60 ± 0.20 | 7.88 ± 0.61 | 7.79 ± 0.84 | 7.93 ± 0.50 | 1.000, 0.99 | 1.037, 0.108 | 1.024, 0.99 | 1.042, 0.99 | |
| 18. | CCDC37 | 9.33 ± 0.52 | 9.48 ± 0.36 | 9.02 ± 0.50 | 9.00 ± 0.86 | 9.04 ± 0.22 | 1.016, 0.99 | −1.051, 0.044 | −1.054, 0.982 | −1.049, 0.701 | |
| 19. | GLI3 | 7.39 ± 0.36 | 6.91 ± 0.25 | 6.73 ± 0.25 | 6.81 ± 0.39 | 6.68 ± 0.15 | −1.069, 0.044 | −1.027, 0.269 | −1.015, 0.99 | −1.034, 0.99 | |
| 20. | ABCC3 | 6.92 ± 0.59 | 7.66 ± 0.52 | 7.31 ± 0.75 | 7.16 ± 0.48 | 7.40 ± 0.89 | 1.106, 0.379 | −1.048, 0.315 | −1.070, 0.99 | −1.034, 0.99 | |
| 21. | SAMD5 | 3.77 ± 0.15 | 4.08 ± 0.33 | 3.75 ± 0.24 | 3.85 ± 0.28 | 3.70 ± 0.22 | 1.082, 0.183 | −1.088, 0.044 | −1.059, 0.953 | −1.104, 0.06 | |
| 22. | RASSF10 | 7.48 ± 0.40 | 6.90 ± 0.79 | 6.81 ± 0.46 | 6.97 ± 0.17 | 6.72 ± 0.56 | −1.083, 0.534 | −1.013, 0.366 | 1.010, 0.99 | −1.027, 0.99 | |
| 23. | USP27X | 7.32 ± 0.36 | 6.88 ± 0.39 | 6.77 ± 0.27 | 6.67 ± 0.19 | 6.82 ± 0.31 | −1.064, 0.168 | −1.016, 0.482 | −1.031, 0.99 | −1.008, 0.99 | |
| 24. | NR0B1 | 3.84 ± 0.18 | 4.68 ± 0.72 | 4.43 ± 0.52 | 4.35 ± 0.47 | 4.48 ± 0.57 | 1.217, 0.041 | −1.056, 0.421 | −1.076, 0.99 | −1.044, 0.99 | |
| 25. | PLAG1 | 5.35 ± 0.50 | 5.23 ± 0.41 | 4.88 ± 0.53 | 4.98 ± 0.50 | 4.82 ± 0.58 | −1.023, 0.99 | −1.072, 0.159 | −1.050, 0.99 | −1.085, 0.99 | |
| 26. | SCGB3A1 | 13.96 ± 0.39 | 13.88 ± 0.75 | 12.87 ± 0.79 | 13.10 ± 1.20 | 12.73 ± 0.49 | −1.006, 0.99 | −1.078, 0.044 | −1.059, 0.642 | −1.090, 0.042 | |
| 27. | LHX6 | 5.55 ± 0.26 | 5.89 ± 0.46 | 6.01 ± 0.46 | 5.91 ± 0.33 | 6.07 ± 0.53 | 1.062, 0.863 | 1.020, 0.269 | 1.003, 0.99 | 1.030, 0.99 | |
| 28. | LINC00942 | 3.64 ± 0.20 | 4.02 ± 0.93 | 3.83 ± 0.44 | 3.77 ± 0.27 | 3.86 ± 0.53 | 1.105, 0.987 | −1.050, 0.841 | −1.066, 0.99 | −1.042, 0.99 | |
| 29. | REEP1 | 8.96 ± 0.75 | 10.11 ± 0.61 | 9.43 ± 0.78 | 8.77 ± 0.41 | 9.84 ± 0.66 | 1.129, 0.028 | −1.072, 0.088 | −1.153, 0.024 | −1.028, 0.99 | |
| 30. | C6orf164 | 5.27 ± 0.44 | 6.38 ± 0.51 | 6.33 ± 0.68 | 6.18 ± 0.35 | 6.42 ± 0.82 | 1.212, 0.016 | −1.008, 0.841 | −1.033, 0.99 | 1.006, 0.99 | |
| 31. | LINC00589 | 5.14 ± 0.20 | 5.42 ± 0.33 | 5.47 ± 0.32 | 5.35 ± 0.20 | 5.55 ± 0.36 | 1.053, 0.609 | 1.009, 0.763 | −1.012, 0.99 | 1.024, 0.99 | |
| 32. | JAKMIP3 | 4.55 ± 0.17 | 5.52 ± 0.60 | 5.26 ± 0.63 | 5.16 ± 0.78 | 5.31 ± 0.58 | 1.214, 0.022 | −1.049, 0.482 | −1.069, 0.99 | −1.039, 0.99 | |
| 33. | LINC00930 | 5.98 ± 0.79 | 7.01 ± 0.41 | 6.34 ± 0.59 | 6.16 ± 0.76 | 6.44 ± 0.52 | 1.172, 0.061 | −1.106, 0.044 | −1.137, 0.348 | −1.088, 0.767 | |
| 34. | DNHD1 | 6.42 ± 0.27 | 7.07 ± 0.51 | 6.94 ± 0.61 | 6.77 ± 0.80 | 7.04 ± 0.53 | 1.100, 0.202 | −1.019, 0.92 | −1.045, 0.99 | −1.004, 0.99 | |
| 35. | TMCC3 | 4.03 ± 0.80 | 4.02 ± 0.55 | 4.43 ± 0.35 | 4.42 ± 0.23 | 4.44 ± 0.42 | −1.002, 0.99 | 1.102, 0.035 | 1.098, 0.99 | 1.105, 0.99 | |
| 36. | ADH7 | 7.63 ± 0.89 | 11.08 ± 0.44 | 10.54 ± 0.63 | 10.48 ± 0.29 | 10.58 ± 0.78 | 1.453, 0.001 | −1.051, 0.044 | −1.058, 0.99 | −1.048, 0.99 | |
| 37. | PRKAR2B | 7.38 ± 0.42 | 6.38 ± 0.55 | 5.97 ± 0.67 | 5.96 ± 0.93 | 5.97 ± 0.55 | −1.158, 0.04 | −1.069, 0.228 | −1.070, 0.99 | −1.068, 0.99 | |
| 38. | GAD1 | 5.22 ± 0.87 | 6.89 ± 1.08 | 7.09 ± 0.86 | 6.85 ± 1.32 | 7.23 ± 0.57 | 1.321, 0.025 | 1.029, 0.688 | −1.007, 0.99 | 1.049, 0.99 | |
| 39. | LOC338667 | 5.32 ± 0.20 | 5.14 ± 0.22 | 5.05 ± 0.29 | 5.02 ± 0.17 | 5.06 ± 0.35 | −1.035, 0.99 | −1.018, 0.315 | −1.024, 0.99 | −1.015, 0.99 | |
| 40. | CYB5A | 4.70 ± 0.17 | 4.58 ± 0.18 | 4.45 ± 0.23 | 4.53 ± 0.27 | 4.41 ± 0.21 | −1.026, 0.99 | −1.029, 0.228 | −1.012, 0.99 | −1.040, 0.81 | |
| 41. | PIEZO2 | 6.64 ± 0.77 | 6.52 ± 0.33 | 6.05 ± 0.61 | 5.86 ± 0.74 | 6.16 ± 0.57 | −1.019, 0.99 | −1.078, 0.159 | −1.111, 0.81 | −1.058, 0.99 | |
| 42. | SLITRK6 | 7.50 ± 0.62 | 6.67 ± 0.96 | 6.46 ± 0.51 | 6.60 ± 0.69 | 6.38 ± 0.42 | −1.125, 0.298 | −1.033, 0.482 | −1.010, 0.99 | −1.046, 0.99 | |
| 43. | KCNA1 | 6.40 ± 1.00 | 5.83 ± 0.82 | 5.20 ± 0.85 | 5.79 ± 0.86 | 4.89 ± 0.69 | −1.098, 0.99 | −1.121, 0.159 | −1.007, 0.99 | −1.193, 0.356 | |
| 44. | LOC100507560 | 5.59 ± 0.52 | 5.20 ± 0.52 | 4.82 ± 0.22 | 4.81 ± 0.18 | 4.83 ± 0.25 | −1.075, 0.638 | −1.079, 0.088 | −1.081, 0.85 | −1.077, 0.655 |
The Adj. P is based on the marginally adjusted 𝑝 values by the Benjamini-Hochberg-FDR correction at α = 0.05; Median ± Interquartile range.