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. 2018 Oct 25;8:15812. doi: 10.1038/s41598-018-34093-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activated endoplasmic reticulum stress in acinar cells of Ptf1a cKO mice. Representative findings of electron microscopy in control mice on day 3 (a) in Ptf1a cKO mice on day 3 (c) in control mice on day 10 (e) and in Ptf1a cKO mice on day 10 (g). (b,d,f,h) are magnified images of (a,c,e,g). Note the dilated ER lumen (indicated by red asterisks) in Ptf1a cKO mice on day 3 (d). Scale bars = 2 μm.