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Representative scheme summarizing the mechanisms and cytokines involved in the differentiation process of Th0 in Th17 cells, and the potential function of these cells in tumor progression. APC, antigen-presenting cell; p-STAT, phosphorylated signal transducer and activator of transcription; IL, interleukin; TGF-β, tumor growth factor β; Th, T helper cell; VEGF, vascular endothelial growth factor; PGE2, prostaglandin E2; NO, nitric oxide; Th0, CD4+ T cells.
