Figure 3.

The visual predictive checks (VPCs) for the population pharmacokinetic‐pharmacodynamic models of warfarin. The left and right plots display the VPCs for the effect‐compartment and turnover models, respectively. For both plots, the blue solid line represents the observed median and the blue dashed lines represent the observed 10th and 90th percentiles. Similarly, for both plots, the red solid line represents the simulated median and the red dashed lines represent the simulated 10th and 90th percentiles. The pink shaded regions indicate 95% confidence intervals for the simulations. AQR, additive quantile regression.