Figure 5.

The visual predictive checks for the hypothetical population pharmacokinetic model with intensive and sparse sampling. The subset of intensive subjects is displayed in the upper left panel. The top right and bottom left panels display trough/sparse sampling for all subjects. For all plots, the blue solid line represents the observed median and the blue dashed lines represent the observed 10th and 90th percentiles. Similarly, for all plots, the red solid line represents the simulated median and the red dashed lines represent the simulated 10th and 90th percentiles. The pink shaded regions indicate 95% confidence intervals for the simulations.