Table 3.
Comparison of the noncompartmental analysis (NCA) results from Peltoniemi et al.9 and the final semimechanistic pharmacokinetic model based on simulations with ncappc package in PsN30
| Compound | PK parameter | S‐ketamine | ||
|---|---|---|---|---|
| p.o. placebo‐phase | i.v. placebo‐phase | p.o. ticlopidine‐phase | ||
| NCA resultsa | ||||
| S‐ketamine | AUC (ng h/mL) | 21 | 76 | 54 |
| C max (ng/mL) | 9.9 | 32 | 17 | |
| Norketamine | AUC (ng h/mL) | 292 | 121 | 310 |
| Cmax (ng/mL) | 61 | 14 | 46 | |
| Model predictionsb | ||||
| S‐ketamine | AUC (ng h/mL) | 22.4 | 70 | 53.2 |
| Cmax (ng/mL) | 9.37 | 41 | 18.1 | |
| Norketamine | AUC (ng h/mL) | 279 | 161 | 250 |
| Cmax (ng/mL) | 56 | 22 | 45 | |
AUC, area under the curve; Cmax, peak plasma concentration; NCA, noncompartmental analysis.
AUC calculated by trapezoidal rule with extrapolation to infinity.
a
Calculated with ncappc package. Model prediction results were obtained simulating the original study design with the final model and 1,000 samples.