Table II.
Expression of IHC markers as categorical variables (high vs. low) throughout the stages of rectal tumorigenesis.
| Lgr5 | SOX2 | CD8 | Foxp3 | PD-L1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value |
| LG | 1.00 | 0.840 | 1.00 | 0.75 | 1.00 | 0.089 | 1.00 | <0.001 | 1.00 | 0.001 | |||||
| LGwHG | 1.25 | 0.35–4.49 | 0.732 | 1.88 | 0.52–6.81 | 0.340 | 3.00 | 0.76–11.8 | 0.116 | 5.73 | 1.01–32.7 | 0.049 | 7.20 | 1.27–40.7 | 0.026 |
| HG | 0.73 | 0.21–2.57 | 0.622 | 1.35 | 0.38–4.80 | 0.643 | 5.14 | 1.30–20.4 | 0.020 | 19.5 | 3.38–112.4 | <0.001 | 25.2 | 4.24–149.8 | <0.001 |
| AdCa | 1.20 | 0.36–4.04 | 0.768 | 1.80 | 0.53–6.14 | 0.348 | 4.33 | 1.16–16.3 | 0.030 | 40.5 | 6.57–249.6 | <0.001 | 24.0 | 4.23–136.2 | <0.001 |
LG, low grade adenoma; LGwHG, low grade adenoma with high grade areas; HG, high grade adenoma; AdCa, adenocarcinoma; Lgr5, leucine-rich repeat-containing G-protein coupled receptor-5; SOX2, sex determining region Y-box 2; CD8, cluster of differentiation 8; Foxp3, forkhead box P3; PD-L1, programmed death-ligand 1; OR, odds ratio; CI, confidence interval.