Table IV.
Univariate and multivariate analyses of prognostic parameters for recurrence-free survival in extrahepatic bile duct cancer and gallbladder cancer.
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Parameters | No. of patients | 5-year survival rate (%) | P-value | Hazard ratio (95% confidence interval) | P-value |
| Tumor diameter, cm | |||||
| <5 | 70 | 36.6 | 0.320 | ND | |
| ≥5 | 12 | 22.9 | |||
| Histopathological grade | |||||
| G1,2 | 60 | 41.5 | 0.005b | 1 | 0.143 |
| G3 | 22 | 12.0 | 1.624 (0.843–2.992) | ||
| Lymphatic permeation | |||||
| Negative | 2 | 40.6 | 0.202 | ND | |
| Positive | 50 | 29.8 | |||
| Blood vessel permeation | |||||
| Negative | 33 | 44.6 | 0.274 | ND | |
| Positive | 49 | 27.2 | |||
| Perineural invasion | |||||
| Negative | 17 | 52.9 | 0.036 | 1 | 0.045b |
| Positive | 65 | 28.8 | 2.132 (1.016–4.941) | ||
| pT factor | |||||
| pT1-2 | 47 | 38.7 | 0.216 | ND | |
| pT3-4 | 35 | 27.8 | |||
| pN factor | |||||
| Negative | 36 | 44.5 | 0.063a | 1 | 0.896 |
| Positive | 46 | 26.0 | 1.043 (0.559–1.978) | ||
| Staging | |||||
| I, II | 44 | 42.2 | 0.079a | 1 | 0.191 |
| III, IV | 38 | 25.0 | 1.484 (0.821–2.700) | ||
| Resection status | |||||
| R0 | 32 | 41.5 | 0.135 | ND | |
| R1 | 50 | 29.4 | |||
| Cytoplasmic expression of CD133 | |||||
| Negative | 20 | 42.0 | <0.001b | 1 | <0.001b |
| Positive | 62 | 12.5 | 2.947 (1.447–5.718) | ||
a
Factors with P<0.100 were selected for further investigation using a multivariate analysis.
b
A statistically significant result. CD133, prominin-1; CI, confidence interval; ND, not determined.