Table III.
Association among histologic type, tumor site and stage in patients <25 years of age with osteosarcoma between 1973 and 2012.
| Variables | Localized, n (%) | Regional, n (%) | Distant, n (%) | P-value |
|---|---|---|---|---|
| Histologic type ICD-O-3 | aP<0.001 | |||
| Osteosarcoma, NOS | 724 (35.0) | 905 (43.8) | 438 (21.2) | |
| Chondroblastic osteosarcoma | 117 (29.7) | 208 (52.8) | 69 (17.5) | |
| Fibroblastic osteosarcoma | 42 (35.9) | 56 (47.9) | 19 (16.2) | |
| Telangiectatic osteosarcoma | 39 (36.4) | 52 (48.6) | 16 (15.0) | |
| Osteosarcoma in Paget disease of bone | 1 (100.0) | 0 (0.0) | 0 (0.0) | |
| Small cell osteosarcoma | 9 (39.1) | 10 (43.5) | 4 (17.4) | |
| Central osteosarcoma | 16 (32.0) | 28 (56.0) | 6 (12.0) | |
| Intraosseous well-differentiated osteosarcoma | 1 (50.0) | 1 (50.0) | 0 (0.0) | |
| Parosteal osteosarcoma | 69 (65.7) | 31 (29.5) | 5 (4.8) | |
| Periosteal osteosarcoma | 16 (57.1) | 10 (35.7) | 2 (7.1) | |
| High-grade surface osteosarcoma | 1 (12.5) | 4 (50.0) | 3 (37.5) | |
| Primary site-labeled | aP<0.001 | |||
| C40.0-Long bones: Upper limb, scapula, and associated joints | 118 (34.3) | 149 (43.3) | 77 (22.4) | |
| C40.1-Short bones of upper limb and associated joints | 5 (50.0) | 5 (50.0) | 0 (0.0) | |
| C40.2-Long bones of lower limb and associated joints | 796 (36.8) | 973 (45.0) | 394 (18.2) | |
| C40.3-Short bones of lower limb and associated joints | 13 (36.1) | 17 (47.2) | 6 (16.7) | |
| C41.0-Bones of skull and face and associated joints | 32 (36.8) | 39 (44.8) | 16 (18.4) | |
| C41.1 Mandible | 23 (39.7) | 30 (51.7) | 5 (8.6) | |
| C41.2 Vertebral column | 13 (41.9) | 13 (41.9) | 5 (16.1) | |
| C41.3 Rib, Sternum, Clavicle and associated joints | 12 (27.3) | 18 (40.9) | 14 (31.8) | |
| C41.4-Pelvic bones, sacrum, coccyx and associated joints | 22 (17.9) | 59 (48.0) | 42 (34.1) | |
| C41.9-Bone, NOS | 1 (16.7) | 2 (33.3) | 3 (50.0) |
a
Statistically significant. P<0.05 was considered to indicate statistically significant difference. P-values were calculated by χ2 tests. NOS, not otherwise specified; n, number; ICD, International Classification of Disease.